Ergotamine types: Because of the theoretic chances of ergotism, the concurrent the means to access azithromycin with ergot derivatives is not recommended (discover area 4.4).
No matter if neutropenia might have been of the means to access rifabutin, a causal link to integration that have azithromycin hasn’t been created (see Part cuatro
Caution is recommended regarding the co-government ones drugs having Azithromycin by the identified enhancing aftereffect of these drugs when put concurrently toward macrolid antibiotic drug erythromycin.
Co-government out of atorvastatin (ten mg daily) and you may azithromycin (500 mg every single day) don’t change the plasma density from atorvastatin (according to a great HMG CoA-reductase inhibition assay). Although not, post-business instances of rhabdomyolysis into the patients getting azithromycin which have statins possess already been advertised.
When you look at the a great pharmacokinetic communications study from inside the compliment volunteers, no significant effect try observed on the plasma levels of carbamazepine otherwise their productive metabolite inside customers researching concomitant azithromycin.
Even when good causal dating was not depending, thought might be provided to brand new regularity regarding overseeing prothrombin go out when azithromycin is utilized in people researching coumarin-type oral anticoagulants
Cisapride try metabolized on the the liver of the chemical CYP 3A4. Given that macrolides inhibit it enzyme, concomitant management off cisapride may cause the rise out-of QT interval prolongation, ventricular arrhythmias and torsades de pointes.
When you look at the a beneficial pharmacokinetic study examining the consequences of 1 amount off cimetidine, considering 2 hours prior to azithromycin, with the pharmacokinetics from azithromycin, no adjustment out of azithromycin pharmacokinetics was viewed.
In the a beneficial pharmacokinetic communications analysis, azithromycin failed to change the anticoagulant effectation of a single fifteen milligrams dose out-of warfarin given so you’re able to suit volunteers. There had been records received about article-marketing age potentiated anticoagulation after co-administration regarding azithromycin and you will coumarin-particular dental anticoagulants.
In a pharmacokinetic study with healthy volunteers that were administered a 500 mg/day oral dose of azithromycin for 3 days and were then administered a single 10 mg/kg oral dose of cyclosporin, the resulting cyclosporin Cmaximum and AUC0-5 were found to be significantly elevated. Consequently, caution should be exercised before considering concurrent administration of these drugs. If co-administration of these drugs is necessary, cyclosporin levels should be monitored and the dose adjusted accordingly.
Co-administration out-of good 600 milligrams unmarried dose out of azithromycin and you will eight hundred mg efavirenz everyday to possess seven days don’t lead to any clinically extreme pharmacokinetic relations.
Co-administration of a single dose of 1200 mg azithromycin did not alter the pharmacokinetics of a single dose of 800 mg fluconazole. Total exposure and half-life of azithromycin were unchanged by the co-administration of fluconazole, however, a clinically insignificant decrease in Cmax (18%) of azithromycin was observed.
Co-administration of 1 amount regarding 1200 mg azithromycin had no mathematically significant impact on the new pharmacokinetics out-of indinavir given because the 800 mg three times everyday for 5 weeks.
Inside healthy volunteers, co-management away from azithromycin 500 milligrams/time to own three days don’t end in clinically tall alterations in the latest pharmacokinetics and you may pharmacodynamics of just one fifteen mg dose of midazolam.
Co-administration off azithromycin (1200 milligrams) and you can nelfinavir from the steady-state (750 milligrams three times everyday) triggered increased azithromycin concentrations. No clinically tall adverse effects was basically observed without amount adjustment is necessary.
In normal healthy male volunteers, there was no evidence of an effect of azithromycin (500 mg daily for 3 days) on the AUC and Cmax of sildenafil or its major circulating metabolite.
Pharmacokinetic studies have advertised no evidence Buddhist dating apps of a conversation ranging from azithromycin and you may terfenadine. There have been rare circumstances reported where in actuality the chances of such as a relationships cannot end up being entirely excluded; but not there is certainly zero particular evidence one to for example a conversation had taken place.